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July 1968

Cerebral Edema in Water Intoxication: II. An Ultrastructural Study

Author Affiliations

New York
From the departments of neurology and pathology, Division of Neuropathology, New York Hospital-Cornell Medical Center, New York. Dr. Torack is now at the Department of Pathology, Washington University School of Medicine, St. Louis.

Arch Neurol. 1968;19(1):79-87. doi:10.1001/archneur.1968.00480010097008

PREVIOUS morphological studies of cerebral edema in water intoxication have been concerned exclusively when gray matter,1-5 although it has been well established that the greatest chemical swelling occurs in white matter.6 Most observers have found an increase in water content of the brain6-10 and swelling of glial cells1,7 in water intoxication, but Gerschenfeld et al have claimed that no chemical or morphological change occurs in the brain in the presence of severe water intoxication.7 In view of this controversy, and because of the often-noted differences in the behavior of white and gray matter in other types of brain swelling,11-16 we undertook this morphological study of white matter edema in water intoxication. It was hoped that such a work, in addition to complementing our chemical data on water intoxication,17 might provide useful information regarding fluid pathways in the brain.

Material and Methods  Thirty

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