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July 1968

Symmetrical Epileptogenic Foci in Monkey Cerebral Cortex: Mechanisms of Interaction and Regional Variations in Capacity for Synchronous Discharges

Author Affiliations

From the Department of Neurology, New England Medical Center Hospitals and Tufts University School of Medicine Boston.

Arch Neurol. 1968;19(1):99-116. doi:10.1001/archneur.1968.00480010117010

WE HAVE previously reported the results of a series of experiments in the cat concerning the interaction of acute relatively large bilateral epileptogenic foci in homologous areas of cerebral cortex1,2 (predominantly posterior sigmoid and suprasylvian gyri). In the intact animal, this interaction often resulted in the rapid production of persistent synchronous and symmetrical patterns of bilateral discharge including 21/2 to 31/2 cycles per second (cps) spike-slow wave complexes. Relevant behavioral concomitants of these bilateral discharges resembled some of the clinical phenomena observed in patients with idiopathic petit mal or grand mal seizures during similar bilateral discharges: bilateral facial muscle and forelimb myoclonus, transient suspension or imperfect continuation of a repetitive act, and occasional generalized convulsive seizures.

Investigations of the underlying anatomical pathways involved in this interaction of bilateral cortical foci indicated the significant role of the corpus callosum. Synchrony of bilateral discharge failed to occur after total

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