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July 1968

Accumulation of Zinc in Mouse Brain: An Autoradiographic Study With 65Zn

Author Affiliations

Umeå, Sweden
From the departments of pathology II (Dr. Hassler), and of prosthetics (Dr. Söremark), University of Umeå, Sweden.

Arch Neurol. 1968;19(1):117-120. doi:10.1001/archneur.1968.00480010135011

IT is well known that the hippocampal region of the brain of most mammals is rich in some heavy metals. In general, the methods used to study the occurrence of heavy metals in this tissue have been the dithizon technique ad modum Maske1 and the sulfide-silver procedure by Timm.2 The dithizon method is relatively specific for zinc. The sulfide-silver procedure does not differentiate between various heavy metals. The positive staining reaction indicating localization of metals notably zinc has mainly been confined to the layer of the mossy fibers in the H3 to H5 portions of the hippocampus.3,4 The physiological significance of the occurrence of this zinc is not known.

Chemical analysis of the rabbit brain5 has shown slightly higher concentrations of zinc in the hippocampus (13.9μg/gm of fresh tissue) than in the cerebellum (10.8), the cerebral cortex (10.5), or the midbrain (8.8). An

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