CARBAMAZEPINE (Tegretol) has been used for more than eight years in other countries for the treatment of epilepsy and, more recently, trigeminal neuralgia. The earliest reports on its effect in trigeminal neuralgia were by Blom1,2 in Sweden, Bonduelle et al3 in France, and Spillane4 and Taylor5 in England. Since then, there have been a number of additional papers.6-9 The authors are in agreement on the effectiveness of this drug in trigeminal neuralgia, but the type and number of side effects have been quite variable. There have been occasional reports of serious hematopoietic effects,10,11 but no repeated blood studies over long periods have been reported. The present study was undertaken to evaluate the side effects and also the application of this drug in some of the other neuralgias such as postherpetic, tabetic, and atypical facial neuralgia. A double-blind technique was necessary.
Carbamazepine is an
James M. Killian, Gerhard H. Fromm. Carbamazepine in the Treatment of NeuralgiaUse and Side Effects. Arch Neurol. 1968;19(2):129–136. doi:10.1001/archneur.1968.00480020015001