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August 1968

Parenteral Isoxsuprine and Nylidrin: Effects on Cerebral and Peripheral Blood Flow

Author Affiliations

Bronx, NY
From the Department of Neurological Surgery, The Albert Einstein College of Medicine, Bronx, NY.

Arch Neurol. 1968;19(2):213-217. doi:10.1001/archneur.1968.00480020099010

ISOXSUPRINE hydrochloride (Vasodilan)1-3 and nylidrin hydrochloride (Arlidin)4 are new and potent vasodilators which have been suggested for use in the treatment of cerebrovascular disorders. Mention of their properties is not included in extensive reviews of the pharmacology of cerebral blood flow (CBF) by Shenkin,5 Sokoloff,6 and Gottstein.7

The object of this study was to demonstrate the effect, if any, upon CBF in a continuously monitored preparation, measuring both cerebral and peripheral blood flow, following parenteral administration of the drugs. Femoral blood flow (FBF) was considered as representative of peripheral blood flow. Total cerebral blood was determined by a direct reading rotameter method,8 and both were compared with the effect of inhalation of 5% carbon dioxide, an established cerebral vasodilator. It was demonstrated that isoxsuprine hydrochloride and nylidrin hydrochloride exert their major effects by increasing the peripheral circulation, but cerebral blood flow is reduced

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