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August 1968

Technetium Tc 99m Serum Albumin: The Use of High Specific Activity Technetium Tc 99m Serum Albumin as a Tracer for Subarachnoidal and Ventricular Scintiphotography

Author Affiliations

Bethesda, Md
From the Section of Neuroradiology, Medical Neurology Branch, National Institute of Neurological Diseases and Blindness (Dr. Di Chiro), the Diagnostic Radioisotope Section, Department of Nuclear Medicine, Clinical Center (Dr. Ashburn), and the Radiopharmaceutical Service, Pharmacy Department, Clinical Center (Capt Briner), National Institutes of Health, Bethesda, Md.

Arch Neurol. 1968;19(2):218-227. doi:10.1001/archneur.1968.00480020104011

OVER the past four years a steadily increasing interest has been evident in investigating the cerebrospinal fluid (CSF) cavities by means of radioisotope scanning techniques (scintiphotography). As a possible indication of this, contributions1-7 from seven different centers were presented on this subject alone at the Eighth Symposium Neuroradiologicum held in September 1967 in Paris. The reports dealt with the clinical applications of these techniques in a number of conditions including intraspinal pathology, hydrocephalus, CSF, rhinorrhea and otorrhea, subarachnoidal cysts, and porencephaly.

Choice of Tracer  Numerous radioactive tracers have been used for studying the spinal and endocranial cerebrospinal fluid pathways by external detection (Table). Among these agents 99mTc-pertechnetate stands out for its almost ideal physical characteristics: 6-hour half-life, lack of β-emission, and single 140 Kev γ-photon. Therefore, sodium pertechnetate (Na-99mTcO4) was tried as agent for isotope cisternography by one of us.12,19 It became apparent,

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