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September 1968

Lipid Metabolism in Cerebral Edema Associated With Human Brain Tumor

Author Affiliations

From the Department of Chemical Pathology, Institute of Neurology, National Hospital, Queen Square, London.

Arch Neurol. 1968;19(3):241-247. doi:10.1001/archneur.1968.00480030019001

DESPITE various investigations into biochemical aspects relating to cerebral edema surrounding brain tumors in man, such as electrolytes,1 proteins,2 and enzyme activities,3 the studies of lipid metabolism in this pathologic process have been very few,4,5 and one of them was in an acute pyogenic process.5 In each example evidence of demyelination was present. Morphologic investigation using the electron microscope in similar pathologic processes, both in human materials6 and in experimental animals, (T. Yanagihara, unpublished data) demonstrated some disturbance in lamination of myelin sheaths. For this reason we have attempted a systematic survey of lipid alterations in relation to the cerebral edema associated with human brain tumors.

Report of Cases  Materials used in this investigation were obtained at autopsy. Short summaries of each clinical history are as follows:CASE 1.—A 64-year-old male patient was hospitalized with a five-month history of temporal lobe epilepsy

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