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Article
November 1968

Granulomatous Angiitis of the Central Nervous System

Arch Neurol. 1968;19(5):510-524. doi:10.1001/archneur.1968.00480050080008
Abstract

AMONG the noninfective inflammatory diseases of the blood vessels is a rare form of granulomatous angiitis that is almost entirely confined to the central nervous system (CNS). The lesions, which are focal and often necrotizing, are generally associated with multinucleate giant cells. Before its delineation as a distinct clinicopathologic entity by Cravioto and Feigin,1 the condition was variously designated as "Morbus Boeck" (Zollinger2), "allergic angiitis and allergic granulomatosis" (Churg and Strauss,3 Newman and Wolf4) and "giantcell arteritis" (McCormick and Neubuerger5). To our knowledge, 14 cases of the disorder have been reported up to now,1,2,4-11 of which two appeared in the form of clinicopathologic discussions in the Cabot case series from the Massachusetts General Hospital.6,7 These two cases, and two additional ones more recently studied at this hospital, are the subject of the present communication. Serial sections of typical lesions from one of the

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