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December 1968

Neurologic Disorders Associated With Increased DNA Synthesis in Peripheral Blood

Author Affiliations

New York
From the Saul R. Korey Department of Neurology, Albert Einstein College of Medicine, New York.

Arch Neurol. 1968;19(6):583-590. doi:10.1001/archneur.1968.00480060053007

THE PERIPHERAL blood of normal persons contains small numbers of deoxyribonucleic acid synthesizing mononuclear cells.1,2 Increased numbers of these cells have been reported in the blood of patients with disorders in which involvement of lymphoid tissue is a prominent feature, notably in certain drug hypersensitivity states, viral infections, immunoglobulin producing neoplasms, and certain "autoimmune" diseases.2-7 Many of the mononuclear cells synthesizing DNA are large, with an intensely basophilic cytoplasm and a primitive nucleus.5-8 They resemble the "blast-like" cells induced in cultures of sensitized lymphocytes exposed to a specific antigen and, also, the proliferating "immunoblast" described by Dameshek in the regional nodes of animals undergoing host-graft rejection.5,8-11 We have shown large numbers of

Autoradiograph of large basophilic mononuclear cell from peripheral blood. Grains represent incorporation of thymidine3H into DNA.

morphologically similar cells synthesizing DNA, rapidly proliferating, and producing antibodies in the lymph nodes, spleen, and blood

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