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December 1968

Spinal Fluid Appearance of

Author Affiliations

Winston-Salem, NC; Los Angeles
From the departments of neurology (Dr. Janeway) and radiology (Drs. Maynard and Witcofski), Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC, and the departments of surgery and physiology, UCLA School of Medicine, The Center for the Health Sciences, Los Angeles (Dr. Lax).

Arch Neurol. 1968;19(6):618-622. doi:10.1001/archneur.1968.00480060088011

THE radiopharmaceutical, 99m Technetium (99mTc), pertechnetate is widely used as an agent for brain scanning. Due to its nearly ideal γ-emission energy (140 kev), short half-life (six hours), and absence of primary particle radiation, relatively large doses can be used so that definition and resolution are quite good with this isotope. At the same time, the radiation dose is reduced when compared to other brain scanning agents. There is relatively little information available explain why certain lesions are associated with abnormal accumulations of radio-activity while others do not show this uptake. To determine whether alterations in permeability might possibly account for some of this variation, we observed the fractional rate at which an intravenously injected dose of 99mTc pertechnetate appeared in the cerebrospinal fluid (CSF) of neurologically normal patients. This report describes our observations.

Materials and Methods  Sterile 99mTc pertechnetate obtained from a molybdenum-Technetium generator