THE radiopharmaceutical, 99m Technetium (99mTc), pertechnetate is widely used as an agent for brain scanning. Due to its nearly ideal γ-emission energy (140 kev), short half-life (six hours), and absence of primary particle radiation, relatively large doses can be used so that definition and resolution are quite good with this isotope. At the same time, the radiation dose is reduced when compared to other brain scanning agents. There is relatively little information available explain why certain lesions are associated with abnormal accumulations of radio-activity while others do not show this uptake. To determine whether alterations in permeability might possibly account for some of this variation, we observed the fractional rate at which an intravenously injected dose of 99mTc pertechnetate appeared in the cerebrospinal fluid (CSF) of neurologically normal patients. This report describes our observations.
Materials and Methods
Sterile 99mTc pertechnetate obtained from a molybdenum-Technetium generator
Janeway R, Maynard CD, Witcofski RL, Lax LC. Spinal Fluid Appearance of. Arch Neurol. 1968;19(6):618–622. doi:10.1001/archneur.1968.00480060088011
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