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The story of thalidomide has been told many times both in the popular press and in scientific publications. This story's end, however, is nowhere in sight; and, like most such endless accounts, it is somewhat boring.
The present book is a clinical analysis of 114 cases of thalidomide-polyneuropathy. It has the virtue of presenting a follow-up of 82 patients, one to eight years after cessation of thalidomide intake. A very detailed analysis of symptoms and signs and their relation to the total intake and duration of thalidomide therapy is presented in 47 tables which makes it easy to gain an overall view of the disorder. The symmetry of the disease is apparent even in the extraordinary variety of strange paresthesiae which persisted for years, and are meticulously recorded by the author. While the relation of polyneuropathy to thalidomide is now generally accepted, the pathogenesis of this disorder remains obscure even
Appenzeller O. Die Thalidomid-Polyneuritis. Arch Neurol. 1969;20(1):113–114. doi:10.1001/archneur.1969.00480070123018
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