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Article
March 1969

Changes in Brain Lactate During Induced Cerebral Seizures

Author Affiliations

New York
From the Dept of Neurology, Cornell University Medical College, New York. Dr. Beresford is now at the University of Colorado School of Medicine, Denver.

Arch Neurol. 1969;20(3):243-248. doi:10.1001/archneur.1969.00480090031003
Abstract

AN UNRESOLVED question is whether during seizures lactic acidosis occurs in brain tissue because cerebral oxygen delivery fails to meet the augmented demands of cerebral oxidative metabolism. Several investigators have reported that brain lactate concentrations increase during experimental seizures in mice, cats, dogs, and monkeys.1-6 Also, during induced generalized and focal seizures in man, falls in jugular venous pH have been observed.7 From these findings it has been inferred that cerebral metabolism rises so sharply during seizures that it outstrips the available oxygen supply, which results in a shift to anaerobic glycolysis and increasing lactate formation by brain tissue.6 However, recent studies from this laboratory imply that brain lactate does not necessarily increase during induced cerebral seizures. Using dogs and monkeys that were artificially ventilated and paralyzed, Plum and his associates8 found that, although cerebral oxygen consumption increased substantially during induced seizures, cerebral blood flow

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