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April 1969

Memory Loss due to Hippocampal Lesions: Report of a Case

Author Affiliations

Ann Arbor, Mich
From the departments of neurology (Drs. DeJong and Itabashi) and pathology (Drs. Itabashi and Olson), University of Michigan Medical Center, Ann Arbor, Mich.

Arch Neurol. 1969;20(4):339-348. doi:10.1001/archneur.1969.00480100015001

MEMORY has been defined as that property of the nervous system whereby it is effective both in the storage and the retrieval of information.1 Instances of "pure" memory loss without associated impairment of other intellectual functions and not complicated by the presence of other neurologic signs or symptoms or by clouded or altered states of consciousness are rarely encountered in neurologic practice or reported in the neurologic literature. Memory loss is most frequently found in association with widespread disturbance of cerebral function in conditions such as senile brain disease, the presenile and other organic psychoses, toxic and deficiency states, encephalitis, posttraumatic and postanoxic sequelae, and after electroshock therapy and status epilepticus.2 In all of these, however, there are usually other associated neurologic abnormalities as well as disturbances of other intellectual functions and of consciousness. Even in those conditions in which the lesions are somewhat localized (Korsakoff-Wernicke encephalopathy,

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