THE COMPLEXITY of data retrieval and burdensome calculations have limited the wide-spread application of the multiprobe inert gas method to the clinical assessment of regional cerebral blood flow (rCBF).
Lassen1 has attempted to overcome this obstacle by observing the analogue readout of the early curve slope as an index of rCBF. Their approach is far simpler than previously described hand or computer calculations.2 However, the analogue method is limited by providing only a flow index rather than calculated rCBF in cc/100 gm/min and by its emphasis of fast flow (cortical) components to the exclusion of white matter flow. This simplified (analogue) modification has been most useful in studying regional autoregulation by observing the early slope before and after the induction of systemic hypertension.
In developing a clinical method to obtain rCBF as an adjunct to carotid arteriography, we considered that it might not be desirable to
Hill R, Clifton J, Gallager T, Potchen EJ. Regional Cerebral Blood Flow in Man: II. Data Acquisition and Analysis. Arch Neurol. 1969;20(4):384–387. doi:10.1001/archneur.1969.00480100060009
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