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April 1969

Cerebral Blood Flow During Convulsions: Alterations Induced in Animals by High Pressure Oxygen

Author Affiliations

Ann Arbor, Mich
From the Department of Physiology, The University of Michigan, Ann Arbor, Mich.

Arch Neurol. 1969;20(4):396-405. doi:10.1001/archneur.1969.00480100072011

EARLIER studies1 on unanesthetized rats have shown that the toxic action of O2 at high pressure (OHP) on the central nervous system has been associated with cyclic synchronous and asynchronous changes in the O2 availability in localized regions of the brain. The nature of these regional PO2 changes suggest they might possibly be due to or associated with regional changes in cerebral blood flow (CBF). The present experiments were carried out in an attempt to get further and more direct evidence concerning such changes in CBF in the rat. The heated thermocouple technique, a refinement of the method used in earlier blood flow studies2 has been used for continuously recording any regional changes in blood flow from chronically implanted flow sensors. Various modifications of this method originally designed by Gibbs3,4 to investigate the blood flow in the internal jugular vein of man were

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