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April 1969

Acid-Base Changes During Lidocaine Induced Seizures in Macaca mulatta

Author Affiliations

Davis, Calif

Arch Neurol. 1969;20(4):406-412. doi:10.1001/archneur.1969.00480100082012

THE central nervous system (CNS) effects of lidocaine have been studied in both animals and man. It has been shown that an inverse relationship exists between the dose of lidocaine required to produce seizures and the arterial carbon dioxide partial pressure (PaCO2).1,2 The CNS responses to local anesthetics during nonrespiratory disturbances of acid-base balance, however, are less well documented. In this regard recent studies may be of interest, namely that a significant metabolic acidosis may occur in conjunction with electroshock or pentylenetetrazol induced seizures.3,4

The present study was undertaken in unanesthetized rhesus monkeys to evaluate lidocaine seizure threshold and acid-base equilibrium. The relationship of these factors as well as the accompanying behavioral and electrical changes was also evaluated. In contrast to most previous studies of local anesthetic drug tolerance arterial plasma lidocaine concentration was measured in addition to the calculation of seizure dosage on the basis