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May 1969

Thymoma and Myopathy: Report of a Case of Myopathy Resembling Muscular Dystrophy and a Granulomatous Thymoma in an Adult Woman

Author Affiliations

Utrecht, Netherlands
From the Department of Pathology, the State University of Utrecht, Netherlands.

Arch Neurol. 1969;20(5):461-467. doi:10.1001/archneur.1969.00480110025002

IN STUDYING cases of mediastinal tumors seen in the Institute of Pathology of the State University of Utrecht, a thymoma, which also showed signs of muscular dystrophy was seen in an adult woman. The association of a tumor of the thymus gland with diseases of muscles other than myasthenia gravis is rare.

Review of Literature  Giordano and Haymond1 reported autopsy findings of a 57-year-old man with a thymoma for 14 years; in many muscles there were pathologic changes of acute and chronic myositis; there was also a focal myocarditis. This patient was reported with a diagnosis of myasthenia gravis. Berkeley Way and Hamilton-Paterson2 described a 72-year-old man with a thymoma presumably for 55 years before onset of muscle weakness. Bonduelle and Bouyges3 described a patient with thymoma and polyneuritis who clinically showed the symptoms of myasthenia gravis; however, according to Oosterhuis,4 thrombosis of the basilar artery

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