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May 1969

Developing and Diseased Muscle.

Arch Neurol. 1969;20(5):564. doi:10.1001/archneur.1969.00480110128018

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Red muscle, white muscle. Fast muscle, slow. Type 1 fibers, type 2. The journals have been full of these terms and papers appear in bewildering array. The profusion of publications attests to the importance of this subject; the "trophic" influence of nerve on muscle has become one of the central issues of neurobiology. One major impetus was the discovery that cross-innervation, the transfer of nerves from fast muscles to slow muscles, changed the physiological characteristics of muscle. Another was the discovery that fiber types could be recognized by histochemical techniques. Victor Dubowitz has been a leader in the study of histochemical reactions in muscle, and this book is a summary of his studies in developing and mature muscle, in cross-innervation experiments, and in human disease. It is not a general review of the entire problem because it concentrates on histochemistry, including technical notes, many tables of experimental results, and numerous

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