THE DIFFERENTIAL response to tenotomy of the fast (pale) and the slow (red) muscles of the rabbit and cat has been examined by several workers. In comparison to fast muscles, the tenotomized soleus (slow muscle) atrophies rapidly1-3 and during this process it becomes increasingly sensitive to depolarizing agents,4 shortens its contraction time,5 and shows striking morphological and histochemical changes by light microscopy.6 In the present study, we report on the electron microscopic aspects of the structural changes in the tenotomized soleus.
Materials and Methods
Rats weighing about 200 to 400 gm were anesthesized with ether, the common Achilles tendon was completely severed from its attachment, and a segment 2 mm in length was excised. Ten rats were used and they were sacrificed (two each time) at 1, 11/2, 2, 3, and 4 weeks after tenotomy. Specimens from tenotomized and control soleus muscles were held at rest
Shafiq SA, Gorycki MA, Asiedu SA, Milhorat AT. Tenotomy: Effect on the Fine Structure of the Soleus of the Rat. Arch Neurol. 1969;20(6):625–633. doi:10.1001/archneur.1969.00480120071006
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