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July 1969

Thalamic Degeneration, Dementia, and Seizures: Inappropriate ADH Secretion Associated With Bronchogenic Carcinoma

Author Affiliations

Chicago and Hines, Ill
From the Neurology Service and the Neuropathology Research Section, Veterans Administration Hospital, Hines, Ill, and the departments of neurology and psychiatry, Northwestern University Medical School, Chicago. Dr. Daniels is now with the Department of Pathology, University of Chicago, Chicago. Dr. Chokroverty is now with the Department of Neurology, Chicago Medical School, Chicago. Dr. Barron is now with the Department of Neurology, Albany Medical College of Union University, Albany, NY.

Arch Neurol. 1969;21(1):15-24. doi:10.1001/archneur.1969.00480130029003

ATIENTS harboring malignant neoplasms may develop neurological and endocrinological disorders in the absence of metastases to the nervous system or endocrine glands.1 The resulting clinical syndromes have been referred to as the "remote" or "nonmetastatic" effects of malignant tumors. The exact incidence of these complications has not been determined. Croft and Wilkinson2 state that nonmetastatic neurological syndromes develop in 2% to 16% of carcinomas, and of these, 65% are neuromuscular in type. The incidence of neurological involvement is highest with pulmonary malignancies. Although hypotheses implicating infectious, nutritional immunological, metabolic, and toxic factors have been suggested.1,3-7 the precise biological basis of these remote effects has not been determined.

We provide here a clinical and anatomical report of a man who presented with dementia, developed inappropriate secretion of the antidiuretic hormone (ADH), and died six months later in status epilepticus. General autopsy revealed a bronchogenic carcinoma which had not

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