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July 1969

Virus-like Particles in Myositis Accompanying Herpes Zoster

Author Affiliations

San Francisco
From the Graduate School of Medical Sciences, University of the Pacific, and the Institute of Neurological Sciences, Pacific Medical Center, San Francisco (Drs. Norris and Dramov and Mrs. Johnson), and the San Joaquin General Hospital, French Camp, Calif (Drs. Norris and Calder).

Arch Neurol. 1969;21(1):25-31. doi:10.1001/archneur.1969.00480130039004

CHOU1 detected myxovirus-like particles by electron-microscopy of muscle biopsies from a patient with chronic polymyositis. Our report concerns two cases of myositis which occurred during herpes zoster; one is of additional interest because of a subacute relapsing course. In both, biopsy revealed muscle degeneration in the presence of virus-like particles.

Report of Cases  CASE 1.—The early course in this case is described in a preliminary report2 and only summarized here. A 50-year-old housewife experienced a burning sensation on the left sole in August 1967. Calf muscle pain appeared. At the neurology clinic on Sept 22, examination disclosed absence of the muscle stretch reflex at the ankle. Characteristic blisters appeared distally on the sole, and herpes zoster of L-5 and S-1 was diagnosed.She gave a history of having previously suffered from similar eruptions in other areas on four occasions over 38 years.2 Arthritic symptoms had been present