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August 1969

Cystic Brain Alteration After Incomplete Placental Abruption in Monkey

Author Affiliations

San Juan, PR
From the Section on Experimental Neuropathology, Laboratory of Perinatal Physiology, National Institute of Neurological Diseases and Stroke, National Institutes of Health, San Juan, PR

Arch Neurol. 1969;21(2):133-141. doi:10.1001/archneur.1969.00480140033003

RHESUS MONKEY infants in rare instances have exhibited brain damage following spontaneously occurring complications of pregnancy or birth. One infant, following a breech delivery, manifested brain pathological findings typical of asphyxia neonatorum.1 More recently, another infant sustained severe brain damage following an incomplete abruptio placentae. The clinical and pathological findings presented by this case are described in detail because of their richness and complexity and because of their significance to the development of models of perinatal brain damage in the experimental animal.

Clinical Status  The expected date of delivery of pregnant monkey I-127 was Nov 22, 1964. When the animal failed to deliver by this date, she was placed under close observation. Repeated abdominal palpation failed to reveal evidence of fetal movements. Fourteen days after the expected date of delivery, the mother was surgically delivered of her infant. It was believed the two week postmature fetus had died

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