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August 1969

Deep Temporal Stimulation in Man: Long Latency, Long Lasting Psychological Changes

Author Affiliations

From the divisions of neurosurgery and psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston. Dr. Stevens is now with the University of Oregon Medical School, Portland, Ore.

Arch Neurol. 1969;21(2):157-169. doi:10.1001/archneur.1969.00480140057006

THE BEHAVIORAL effects of electrical stimulation in the deep structures of the temporal lobe in animals and man have been detailed by many investigators.1-12 Due to the operative procedure in progress, most studies in man have been concerned with immediate behavioral and subjective effects. More recent investigations, employing chronic implanted electrodes for stimulation and recording, also deal primarily with the consequences of stimulation during and after the few seconds or minutes during which the current is applied.13,14 The use of chronic implanted electrodes over extended periods permits a search for correlation of spontaneous or electrically induced abnormalities in electroencephalogram with behavior and subjective state under relatively natural conditions. Although recording from chronic indwelling cerebral electrodes from normal individuals has not been reported, records from nonepileptic subjects with mental retardation, intractable pain, and psychiatric disorders suggest that the cortex and subcortical nuclei of the temporal lobe normally present a

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