REGENERATION of striated muscle follows different types of injury. After ischemic necrosis, muscle can be repaired to complete normality. In rabbit, ligation of the anterior tibial artery results in necrosis of the distal two thirds of the muscle. By intensive proliferation of cells that may originate from the satellite cells of Mauro,1 muscle is restored within 90 days by a cycle that strongly resembles histogenesis during ontogeny of muscle.2-4 In this paper, the results of morphologic studies on the regeneration of the anterior tibial muscle are described and compared to ontogeny of rabbit muscle. The biochemical changes in enzymes of regenerating muscle are reported in a second paper.5
Materials and Methods
Fifteen adult rabbits of different species, origin, and sex were used. Weights varied between 2,350 and 5,100 gm. The anterior tibial artery of the right hind limb was prepared as suggested by Clark et al
Kaspar U, Wiesmann U, Mumenthaler M. Necrosis and Regeneration of the Tibialis Anterior Muscle in Rabbit: I. Histological Changes Following the Ligation of the Tibialis Anterior Artery. Arch Neurol. 1969;21(4):363–372. doi:10.1001/archneur.1969.00480160035004
Monkeypox Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.