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November 1969

Effects of Diuretics and Steroids on CSF Pressure: A Comparative Study

Author Affiliations

Richmond, Va
From the Laboratories of Experimental Neurology and Neurochemistry, Division of Neurology, Medical College of Virginia, Richmond, Va.

Arch Neurol. 1969;21(5):499-509. doi:10.1001/archneur.1969.00480170071007

STEROIDS1-24 (especially prednisolone and dexamethasone) and hypertonic solutions25,26 (especially urea27-30 and mannitol31-35) have been used for the medical treatment of increased intracranial pressure. Each drug has advocates and opponents. Among other controversial subjects, the phenomenon of "rebound overshoot"36-39 has remained unsolved. There are some38 who emphasize the importance of the presence of the secondary overshoot of pressure after the use of hypertonic solutions, and others37 who deny this phenomenon.

The purpose of this study is to compare the effects of the hypertonic solutions as well as steroids on cerebrospinal fluid (CSF) pressure in normal and pathological states with special reference to pressure changes and the problem of "overshoot." To begin with, it was suspected that the above mentioned drugs may have a different effect on normal vs pathological states of the brain and CSF pressure. For this reason, the study was carried