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December 1969

Sphingomyelin in Lewy Inclusion Bodies in Parkinson's Disease

Author Affiliations

From the Department of Neurology, Laboratory of Experimental Neurology, Wilhelmina Gasthuis, University of Amsterdam, Amsterdam.

Arch Neurol. 1969;21(6):615-619. doi:10.1001/archneur.1969.00480180071006

THE INCLUSION bodies, which were later to receive his name, were first described by Lewy1 in the substantia innominata and the dorsal vagal nucleus in paralysis agitans.

Trétiakoff2 described these bodies in the substantia nigra.

Greenfield and Bosanquet3 found Lewy bodies in the substantia nigra in 18 of 19 cases of idiopathic paralysis agitans and in the locus ceruleus in the 19th case (substantia nigra not present). In none of the ten cases of postencephalitic parkinsonism and none of the 22 control subjects of the same age but without parkinsonism were Lewy bodies found.

Lipkin4 studied 53 patients with Parkinson's disease and found Lewy bodies in 44% of the postencephalitic cases and 86% of the idiopathic cases.

Bethlem and den Hartog Jager5 corroborated the findings of Greenfield and Bosanquet3 in an investigation of the substantia nigra and locus ceruleus in 15 patients with

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