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February 1970

Kleine-Levin Syndrome: A Case With EEG Evidence of Periodic Brain Dysfunction

Author Affiliations

Phoenixville, Pa
From the Neurology Service, Department of Medicine, Valley Forge General Hospital (US Army), Phoenixville, Pa. Dr. Green is now at Neurology Service, Department of Medicine, Youngstown Hospital, Youngstown, Ohio, and Dr. Cracco is now at Department of Neurology, Jefferson Medical College, Philadelphia.

Arch Neurol. 1970;22(2):166-175. doi:10.1001/archneur.1970.00480200072008

THE Kleine-Levin syndrome, first described by Kleine1 in 1925 and Levin2 in 1929, is composed of recurring episodes of sleepiness lasting days, associated with excessive appetite and often with abnormal behavior. It usually affects male adolescents. It is rare; Sours3 did not find one case in reviewing 115 patients with excessive sleepiness who were evaluated at the Columbia-Presbyterian Medical Center from 1932 to 1961. Critchley4 stated that only 26 acceptable cases had been reported up to 1962, including 11 personal cases. Since then several more cases have been reported.5-11

The etiology of the Kleine-Levin syndrome is unknown. Laboratory investigations, including electroencephalographic studies have not revealed abnormalities of the cerebral functions examined.4,5,7,9,10,12-14 We describe the case of a patient with the Kleine-Levin syndrome who had markedly abnormal electroencephalogram findings only during episodes of hypersomnolence.

Report of a Case  A 19-year-old white male patient was

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