THE Kleine-Levin syndrome, first described by Kleine1 in 1925 and Levin2 in 1929, is composed of recurring episodes of sleepiness lasting days, associated with excessive appetite and often with abnormal behavior. It usually affects male adolescents. It is rare; Sours3 did not find one case in reviewing 115 patients with excessive sleepiness who were evaluated at the Columbia-Presbyterian Medical Center from 1932 to 1961. Critchley4 stated that only 26 acceptable cases had been reported up to 1962, including 11 personal cases. Since then several more cases have been reported.5-11
The etiology of the Kleine-Levin syndrome is unknown. Laboratory investigations, including electroencephalographic studies have not revealed abnormalities of the cerebral functions examined.4,5,7,9,10,12-14 We describe the case of a patient with the Kleine-Levin syndrome who had markedly abnormal electroencephalogram findings only during episodes of hypersomnolence.
Report of a Case
A 19-year-old white male patient was
Green LN, Cracco RQ. Kleine-Levin Syndrome: A Case With EEG Evidence of Periodic Brain Dysfunction. Arch Neurol. 1970;22(2):166–175. doi:10.1001/archneur.1970.00480200072008
Artificial Intelligence Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.