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June 1970

Regional Cerebral Blood Flow in Dogs: Local and Remote Effect of Carbon Dioxide

Author Affiliations

Miami. Fla
From the Department of Neurology, University of Miami School of Medicine, Miami, Fla. Dr. Kogure is now with the Second Department of Internal Medicine, Jikei University School of Medicine, Tokyo.

Arch Neurol. 1970;22(6):528-540. doi:10.1001/archneur.1970.00480240048008

THE RESPONSE of cerebral circulation to changes in arterial carbon dioxide pressure (Pco2) is well known, but the mechanisms whereby carbon dioxide (CO2) alters the tone of cerebral vessels are still uncertain. It has been generally accepted that CO2 acts directly upon vascular smooth muscle, although some of the evidence for this is tenuous.1 Recent studies by Severinghaus and Lassen,2 as well as Betz and Heuser3 imply that CO2 acts by altering the pH of vascular smooth muscle, and that an ion-impermeable barrier between intima and muscularis inhibits a similar effect by decreased arterial pH alone. Studies by Shalit et al1,4,5 oppose the concept of a direct effect of CO2 on vessel walls and suggest that one of the mechanisms of action of CO2 on cortical vessels might be indirect through the brain stem. Certainly the hypothesis that the

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