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June 1970

Intracytoplasmic Acidophilic Granules in the Substantia Nigra: A Light and Electron Microscopic Study

Arch Neurol. 1970;22(6):550-555. doi:10.1001/archneur.1970.00480240070010

SMALL acidophilic granules can often be found within cytoplasm of a few of the melanin-containing neurons of the substantia nigra. These inclusions were apparently first described in 1902 by Marinesco1 who compared them to the granulations amphophiles found in the locus ceruleus. More recently a number of other workers have mentioned them briefly. Lipkin2 observed eosinophilic granules the same size as the neuromelanin in normal individuals. Using the Mallory trichrome technique, Foley and Baxter3 described red staining granules in both children and adults. Lillie and Yamada4 found eosinophilic intracytoplasmic granules in six patients whose ages ranged from 7 to 76. On the basis of their histochemical studies they concluded that the granules contained protein. Earle5 regarded eosinophilic inclusions as one of the nonspecific findings in patients with parkinsonism. Identical inclusions have been observed in a patient with cerebrovascular disease (J.M. Moossy, written communication, Oct