RECURRENT polyneuropathy is a rare disorder, especially cases with more than one relapse. Reports of necropsied cases are extremely rare.
It is the purpose of this paper to describe the clinical and pathological features of a patient with recurrent polyneuropathy who had many relapses over a period of 31 years. The unusual clinical picture was associated with striking findings at necropsy: there was widespread, but focal, infiltration by lymphoid cells of the peripheral nerves and their ganglia as well as of the leptomeninges and the larger Virchow-Robin spaces of the entire central nervous system (CNS), suggesting a lymphoproliferative process. This combination of clinical and pathological findings has not been previously described in man, but there is considerable resemblance to the disorder known in veterinary medicine as Marek's disease or neurolymphomatosis gallinarum, a polyneuropathy of chickens which recent studies have shown to be of probable viral etiology.
Report of a
Borit A, Altrocchi PH. Recurrent Polyneuropathy and Neurolymphomatosis. Arch Neurol. 1971;24(1):40–49. doi:10.1001/archneur.1971.00480310068006
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