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Article
January 1971

Histochemical and Ultrastructural Changes in Rat Muscle: Occurrence Following Adrenal Corticotrophic Hormone, Glucocorticoids, and Starvation

Arch Neurol. 1971;24(1):83-93. doi:10.1001/archneur.1971.00480310111012
Abstract

THE SPECIFIC effects of glucocorticoids on muscle histology have attracted much attention since the recognition that these compounds could induce muscle weakness. Although there have been numerous reports of the light microscopic and ultrastructural changes in muscle under these circumstances,1-10 they have not been correlated with the histochemical alterations.11 Furthermore, the type of muscle fiber most severely affected has not been clarified, with considerable variation in these observations amongst various reports.6,11,12 Part of this inconsistency can be attributed to the species variation of muscle, as measured by the morphological differences and by the pathological response to glucocorticoids. In this report, the enzyme histochemical and ultrastructural changes in rat muscle following adrenal corticotrophic hormone (ACTH), glucocorticoids, and starvation will be described, in addition to changes in average muscle fiber diameters.

Materials and Methods  Forty-eight Osborn-Mendel rats, weighing 237 to 494 gm, were used. The food containers and

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