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March 1971

Amphetamines and Related Compounds: Proceedings of the Mario Negri Institute for Pharmacological Research in Milan, Italy.

Arch Neurol. 1971;24(3):284. doi:10.1001/archneur.1971.00480330112012

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An international symposium was held at the Mario Negri Institute for Pharmacological Research in Milan, Italy. The participants presented 59 papers dealing with the chemistry, metabolism, and pharmacology of amphetamine and its numerous analogues. The scope of this collection of papers and the depth of the individual presentations will assure this volume a lasting place as a major reference work on the subject. Structure-activity relationships of the amphetamines are reviewed. New data are presented on the metabolism of amphetamines. Particular attention is devoted to the interaction of amphetamines with the biogenic amines. Although the bulk of the work discussed derives from animal investigations, chiefly in the rat, much of it is directly relevant to contemporary clinical problems such as chronic amphetamine intoxication and the behavioral and psychotomimetic properties of the amphetamines. There are eight papers dealing with clinical studies on the effects of amphetamine on the eye, sleep, the

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