The brain antipyrine, red blood cell (RBC), albumin, and technetium spaces have been studied in the experimental animal. Control animal brains were compared with edematous brains, in which edema was induced either by water intoxication or triethyl tin. Both types of edema were characterized by a decrease in the RBC and albumin spaces. These observations and the ability to develop techniques with multiple isotopes suggest that it may be possible to recognize clinically and differentiate more subtle forms of brain swelling than is now possible with conventional brain scanning.
Cerebral edema; triethyltin edema; brain spaces; water intoxication.
Potchen EJ, Adatepe MH, Studer R, Penkoske M, Penkoske P, Perez C. Radioisotopic Assessment of Cerebral Edema. Arch Neurol. 1971;24(4):287–290. doi:10.1001/archneur.1971.00480340019001