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Article
April 1971

Interstitial Hypertrophic Neuropathy: Biochemical Study of the Peripheral Nervous System

Author Affiliations

Albany, NY
From the Research Service (Neurology and Pathology), Veterans Administration Hospital, the departments of neurology and pathology, Albany Medical College of Union University, Albany, NY (Drs. Koeppen and Stehbens), and the VA Hospital, Hines, Ill (Dr. Messmore).

Arch Neurol. 1971;24(4):340-352. doi:10.1001/archneur.1971.00480340072008
Abstract

Peripheral nerve tissue of a patient with an electron microscopically verified interstitial hypertrophic neuropathy contained excessive amounts of water and protein but less lipid than comparable control tissue. In the tissue hydrolyzate, hydroxyproline was increased fourfold, hexosamines, twofold. The reduction of lipid was associated with higher than normal levels of cholesteryl esters. The fatty acid profile of the triglycerides, cholesteryl esters, and phospholipids showed abnormally high concentrations of stearic acid and increased stearic acid-oleic acid ratios. The lipids of myelin isolated from the diseased peripheral nerve had most of the characteristics of human peripheral myelin (lower cholesterol and galactolipid than central nervous system myelin) but differed by a higher concentration of choline phosphoglycerides.

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