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May 1971

Experimental Cerebral Fat Embolism: Distribution of Radioactive Triolein Following Internal Carotid Introduction

Author Affiliations

Temple, Tex; Las Vegas, Nev
From the Department of Neurosurgery, Scott-White Clinic, Temple, Tex (Dr. Robinson), and the Department of Pathology, Southern Nevada Memorial Hospital, Las Vegas, Nev (Dr. Soloway).

Arch Neurol. 1971;24(5):419-422. doi:10.1001/archneur.1971.00480350053005

Injection of radioactive fat emboli into the internal carotid artery of rabbits resulted in rapid death in some animals. Death was preceded by hypertension and Cheyne-Stokes respirations. These animals showed an increased retention of fat emboli within the brain, and a disproportionately high recovery from the pons and midbrain, compared to animals which were killed. The data suggest that the death mechanism was brain stem ischemia followed by a vasomotor ischemic reflex, which in turn resulted in vasospasm and hypertension. The choroid plexus was found to be the most efficient filter for fat emboli within the brain on a per gram basis.