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June 1971

Virus Antibodies and Multiple Sclerosis

Author Affiliations

Bethesda, Md; Washington, DC; Minneapolis; Burlington, Vt; Bethesda
From the Section on Infectious Diseases, Perinatal Research Branch (Dr. Sever and Miss Gilkeson), Section on Mathematical Statistics, Office of Biometry (Dr. Ellenberg), and Epidemiology Branch (Dr. Brody), National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, Md; the Neurology Service (Dr. Kurtzke), Veterans Administration Hospital, Washington, DC; the Neurology Service (Dr. Alter), Veterans Administration Hospital, Minneapolis; and Division of Neurology (Dr. Schumacher), College of Medicine, University of Vermont, Burlington, Vt.

Arch Neurol. 1971;24(6):489-494. doi:10.1001/archneur.1971.00480360023002

Virus antibody levels were determined for multiple sclerosis patients and matched controls from three different locations. For rubeola, several different antigen preparations were used. Measles antibody titers were significantly elevated in multiple sclerosis patients in Washington, DC, increased in the patients in Minneapolis, and somewhat elevated in the patients in Vermont. In the Vermont series, the trend for high measles antibody levels only became apparent when sibling controls were excluded from the analysis. Antibody levels for respiratory syncytial virus, adenovirus, mumps, and varicella were also increased among multiple sclerosis patients in individual groups, but this was not consistent for all three groups.