Virus antibody levels were determined for multiple sclerosis patients and matched controls from three different locations. For rubeola, several different antigen preparations were used. Measles antibody titers were significantly elevated in multiple sclerosis patients in Washington, DC, increased in the patients in Minneapolis, and somewhat elevated in the patients in Vermont. In the Vermont series, the trend for high measles antibody levels only became apparent when sibling controls were excluded from the analysis. Antibody levels for respiratory syncytial virus, adenovirus, mumps, and varicella were also increased among multiple sclerosis patients in individual groups, but this was not consistent for all three groups.
Sever JL, Kurtzke JF, Alter M, et al. Virus Antibodies and Multiple Sclerosis. Arch Neurol. 1971;24(6):489–494. doi:10.1001/archneur.1971.00480360023002
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