Myelin was purified from control and multiple sclerosis (MS) white matter. Purity of samples was checked with electron microscopy and biochemical analyses, and protein composition of myelin samples was evaluated with horizontal gel electrophoresis. Results showed a typical and consistent pattern in electropherograms with major protein constituents and some minor ones. All other proteins were similar in control and MS myelin samples except the encephalitogenic (basic) protein which showed decreased values in MS myelin. The role of encephalitogenic protein in the pathogenesis of MS is discussed on the basis of these findings.
Riekkinen PJ, Palo J, Arstila AU, et al. Protein Composition of Multiple Sclerosis Myelin. Arch Neurol. 1971;24(6):545–549. doi:10.1001/archneur.1971.00480360079010
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