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June 1971

Motor Dysfunction as a Permanent Complication of Methanol Ingestion: Presentation of a Case With a Beneficial Response to Levodopa Treatment

Author Affiliations

St. Louis
From the departments of neurology (Drs. Guggenheim, Couch, and Weinberg) and pediatrics (Drs. Guggenheim and Weinberg), Washington University School of Medicine, and the Division of Neurology, St. Louis Children's Hospital, St. Louis. Dr. Guggenheim is now with the University of Colorado Medical Center, Denver.

Arch Neurol. 1971;24(6):550-554. doi:10.1001/archneur.1971.00480360084011

In a suicidal attempt by a 13-year-old white girl, methanol produced classical immediate symptoms and permanent damage to the central nervous system characterized by severe bilateral optic atrophy, rigidity, spasticity, and hypokinesis. Administration of levodopa has resulted in significant functional relief of the rigidity in this patient. It is suggested that this is the first case report in English describing permanent neurologic sequelae other than optic atrophy as a result of methanol ingestion. The physiologic basis is unknown. Further clinicopathologic correlation should be easily elucidated through reevaluation and longitudinal follow-up of other patients having ingested methanol.

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