Air and iodinated I 131 serum albumin ventriculograms were compared in nine patients with hydrocephalus, and the following conclusions were reached: (1) The intraventricular injection of iodinated I 131 serum albumin is followed by a prompt and general mixing of the radioisotope with the cerebrospinal fluid (CSF). (2) The radioisotope flows with the CSF and serves to demonstrate pathways of circulation in a relatively dynamic way. (3) The radioisotope penetrates intraventricular, interventricular, and periventricular structures with relative ease and produces a typical "double-density" pattern on the two-hour ventricular scan: a dense inner zone (corresponding to the contour of the ventricular system as defined by air) and a less dense outer zone (corresponding to the isotope in the brain surrounding the ventricles). (4) The eventual distribution of the isotope is complex and is dictated in each case by the pathological features of the illness.
Milhorat TH, Hammock MK. Isotope Ventriculography: Interpretation of Ventricular Size and Configuration in Hydrocephalus. Arch Neurol. 1971;25(1):1–8. doi:10.1001/archneur.1971.00490010011001
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