A group of patients receiving levodopa was given psychometric (Wechsler Adult Intelligence Scale) and personality (Minnesota Multiphasic Personality Inventory [MMPI]) measures at one and six months, and then were compared with a control group who had received traditional treatment (anticholinergic drugs and/or thalamotomies) over a similar time period. Generally, on the Wechsler intelligence quotients test patient performances on the control group declined, and performances on the levodopa group improved. Practical and statistically significant group differences were obtained on verbal (9.6 IQ points), performance (7.7), and full scale (9.0) IQ's at six months. No consistent group differences over the six-month period were obtained on the MMPI, but the typical elevation of scale 3 (depression) found on neurologically impaired patients occurred.
Beardsley JV, Puletti F. Personality (MMPI) and Cognitive (WAIS) Changes After Levodopa Treatment: Occurrence in Patients With Parkinson's Disease. Arch Neurol. 1971;25(2):145–150. doi:10.1001/archneur.1971.00490020063007
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