The local effects of hypoxia induced by inhalation of 6% oxygen-nitrogen gas mixture on cortical blood flow of dogs, measured by heat clearance, are variable, whereas the ratio of cerebral venous pressure to mean arterial pressure as an indication of cerebral vascular conductance, uniformly increased. Local cortical flow decreased in one third of animals during hypoxia, but all showed an increased local flow in all areas studied to hypercapnia. The mechanism for a vasoconstrictive response to hypoxia in local cortical regions is not understood.
Fujishima M, Scheinberg P, Busto R. Cerebral Cortical Blood Flow: Variable Effects of Hypoxia in The Dog. Arch Neurol. 1971;25(2):160–167. doi:10.1001/archneur.1971.00490020078009
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