A 29-year-old woman with generalized arterial fibromuscular hyperplasia had a stroke. Fibromuscular hyperplasia involved internal carotid, renal, coronary, splenic, internal iliac, and femoral arteries. Although internal carotid occlusion was bilateral, the cerebral circulation was compensated by adequate collaterals. The patient, who was taking oral contraceptive medication, died when multiple arterial thromboses interruped collateral circulation to the brain. Although the antiovulant probably caused the vascular thromboses and may have influenced the florid progression of the fibromuscular hyperplasia, it is unlikely that it was otherwise etiologically related to the vascular disease.
Hartman JD, Young I, Bank AA, Rosenblatt SA. Fibromuscular Hyperplasia of Internal Carotid Arteries: Stroke in a Young Adult Complicated by Oral Contraceptives. Arch Neurol. 1971;25(4):295–301. doi:10.1001/archneur.1971.00490040021002
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