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October 1971

Central Pontine Myelinolysis in Childhood

Author Affiliations

Brooklyn, NY; Bethesda, Md
From the Department of Pathology, Downstate Medical Center, Kings County Hospital, Brooklyn, NY, and the National Institutes of Health, Bethesda, Md. Dr. Valsamis is now with the Albert Einstein College of Medicine, Bronx, NY, and Dr. Wright is now with the McLeod Infirmary, Florence, SC.

Arch Neurol. 1971;25(4):307-312. doi:10.1001/archneur.1971.00490040033004

The cause of central pontine myelinolysis is not known. A relationship to alcoholism has been postulated while others have stressed liver disease as primary. Three cases in children all Without any history of alcoholic intake are reported. The common feature in all three cases is severe liver disease. The primary disease processes were respectively (1) Hodgkins disease, (2) infectious hepatitis, and (3) craniopharyngioma with pituitary insufficiency after treatment. These three cases strengthen the argument for the importance of liver disease in the pathogenesis of the disease.

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