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November 1971

The Neuropathy of Multiple Myeloma: An Electrophysiological and Histological Study

Author Affiliations

Sydney, Australia
From the Department of Medicine, University of Sydney, Royal Prince Alfred Hospital, Sydney, Australia, and the Repatriation General Hospital, Concord NSW, Australia.

Arch Neurol. 1971;25(5):404-414. doi:10.1001/archneur.1971.00490050038003

Clinical and electrophysiological studies were performed on 23 subjects with multiple myeloma. Three subjects had clinical and electrophysiological evidence of a peripheral neuropathy, and six subjects without clinical evidence of a neuropathy had a diffuse impairment of motor and sensory conduction, an overall incidence of 39%. Sural nerve biopsies were examined from five affected subjects. The primary pathological lesion was found to be axonal degeneration resulting in a loss of both myelinated and unmyelinated fibers.

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