Tuberous sclerosis may present in the newborn period as a seizure disorder characterized as infantile spasms. An important diagnostic sign is the presence of multiple hypopigmented macules which may precede, by several years, the development of other manifestations of the disease.
Roth JC, Epstein CJ. Infantile Spasms and Hypopigmented Macules: Early Manifestations of Tuberous Sclerosis. Arch Neurol. 1971;25(6):547–551. doi:10.1001/archneur.1971.00490060081008
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