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December 1971

Infantile Spasms and Hypopigmented Macules: Early Manifestations of Tuberous Sclerosis

Author Affiliations

San Francisco
From the Department of Pediatrics, University of California, San Francisco.

Arch Neurol. 1971;25(6):547-551. doi:10.1001/archneur.1971.00490060081008

Tuberous sclerosis may present in the newborn period as a seizure disorder characterized as infantile spasms. An important diagnostic sign is the presence of multiple hypopigmented macules which may precede, by several years, the development of other manifestations of the disease.