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May 1972

Muscular Dystrophy and Other Myopathies: Troponin Activity of Natural Actomyosin From Skeletal Muscle

Author Affiliations

Los Angeles
From the Department of Medicine, UCLA School of Medicine, Los Angeles. Dr. Furukawa is a post-doctoral fellow of the Muscular Dystrophy Associations of America and is presently with the Department of Neurology, Institute of Brain Research, School of Medicine, University of Tokyo, Tokyo.

Arch Neurol. 1972;26(5):385-390. doi:10.1001/archneur.1972.00490110019001

Troponin activity of natural actomyosin in various muscle diseases was determined. The activities were expressed as the trypsin-sensitive calciumbinding of natural actomyosin. Among various muscle diseases, muscular dystrophy, especially the Duchenne type, showed greatly decreased values. These decreases may be directly relevant to the dysfunction of the affected muscle. In female carriers of Duchenne dystrophy, one showed normal and the other showed slightly decreased values. Polymyositis, thyrotoxic myopathy, myotonic dystrophy, and paramyotonia congenita revealed normal troponin activities. Nemaline myopathy showed slightly decreased values. Troponin activity was fairly well preserved in advanced neurogenic atrophy.

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