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July 1972

Prolonged Control of Increased Intracranial Pressure With Glycerin

Author Affiliations

Ann Arbor, Mich; Los Angeles; Ann Arbor, Mich
From the Department of Neurology, University of Michigan Medical Center, Ann Arbor, Mich (Drs Newkirk and Reinglass), and the Research and Neurology Service, Veterans Administration Hospital, Wadsworth, Los Angeles, and the Department of Neurology, UCLA School of Medicine, Los Angeles (Dr. Tourtellotte). Dr. Newkirk is now with Letterman General Hospital, Presidio, San Francisco.

Arch Neurol. 1972;27(1):95-96. doi:10.1001/archneur.1972.00490130097015

Glycerin, an oral osmotic agent, causes rapid dehydration of brain without hemolysis, overshoot rehydration of the central nervous system, and electrolyte disturbance or immunosuppression. It can be used effectively for prolonged periods in the face of adequate fluid and electrolyte supplementation. There is no toxicity associated with oral administration and only negligible amounts of glycerin pass the blood-brain barrier. Nausea and vomiting occur with large undiluted doses.

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