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October 1972

Primary Progressive Multifocal Leukoencephalopathy: A Central Nervous System Disease Caused by a Slow Virus

Author Affiliations

From the Department of Pathology, Baptist Memorial Hospital, and the departments of pathology and neurology, University of Tennessee College of Medicine, Memphis.

Arch Neurol. 1972;27(4):357-360. doi:10.1001/archneur.1972.00490160085012

In case of primary progressive multifocal leukoencephalopathy, light microscopy demonstrated amphophilic intranuclear inclusion bodies, and electron microscopy confirmed the presence of papova-like and myxovirus in glial cells. The hypothesis is offered that the disease is caused by a slow virus, not necessarily having an altered immune mechanism as a prerequisite for its propagation, and that altered immunity may provide a more favorable background for its proliferation.

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