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November 1972

Diphenylhydantoin-Induced Cerebellar Degeneration

Author Affiliations

From the departments of medicine, pediatrics, and radiology, and the Division of Neurology, Case Western Reserve University School of Medicine, and University Hospital, Cleveland.

Arch Neurol. 1972;27(5):453-455. doi:10.1001/archneur.1972.00490170085012

Two patients received large amounts of diphenylhydantoin for 28 months or more. While receiving diphenylhydantoin, they acquired severe cerebellar deficits and a peripheral neuropathy that was irreversible. In each case, marked cerebellar atrophy was demonstrated by pneumoencephalography. The cerebellar atrophy and irreversible dysfunction in these two cases is attributed to long-term, high dosages of diphenylhydantoin.