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November 1972

Polymyositis and Penicillamine

Author Affiliations

Madison, Wis
From the University of Wisconsin Medical Center, Department of Neurology, Madison.

Arch Neurol. 1972;27(5):456-457. doi:10.1001/archneur.1972.00490170088013

A 23-year-old asymptomatic woman, known to be homozygous for Wilson's disease, developed polymyositis while receiving prophylactic penicillamine. Symptoms abated when penicillamine was discontinued. Possible effects of penicillamine on immune mechanisms are discussed. The symptoms of Wilson's disease and polymyositis may be difficult to differentiate.