A 23-year-old asymptomatic woman, known to be homozygous for Wilson's disease, developed polymyositis while receiving prophylactic penicillamine. Symptoms abated when penicillamine was discontinued. Possible effects of penicillamine on immune mechanisms are discussed. The symptoms of Wilson's disease and polymyositis may be difficult to differentiate.
Schraeder PL, Peters HA, Dahl DS. Polymyositis and Penicillamine. Arch Neurol. 1972;27(5):456–457. doi:10.1001/archneur.1972.00490170088013
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